VOX LUX begins in 1999 when teenage sisters Celeste (Raffey Cassidy) and Eleanor (Stacy Martin) survive a seismic, violent tragedy. The sisters compose and perform a song about their experience, making something lovely and cathartic out of catastrophe - while also catapulting Celeste to stardom. By 2017, the now 31-year-old Celeste (Natalie Portman) is the mother to a teenage daughter of her own and struggling to navigate a career fraught with scandals when another act of terrifying violence demands her attention.