The film stars Gabriel LaBelle (The Predator, American Gigolo series) as 16-year-old aspiring filmmaker Sammy Fabelman; four-time Academy Award nominee Michelle Williams (Manchester by the Sea, My Week with Marilyn) as his artistic mother, Mitzi; Paul Dano (The Batman, There Will Be Blood) as his successful, scientific father, Burt; Seth Rogen (Steve Jobs, An American Pickle) as Bennie Loewy, Burt's best friend and honorary "uncle" to the Fabelman children, and Academy Award(R) nominee Judd Hirsch (Uncut Gems, Ordinary People) as Mitzi's Uncle Boris.