Jackie Gleason and Art Carney are a hilarious team again, this time as out-of-work vaudeville actors turned prohibition agents. Isadore Einstein and Morris Smith are two unorthodox federal agents who are highly publicized and very creative Roaring Twenties crimestoppers. Gleason's Einstein believes, "serious jobs can be done with a little style and humor." And with a little style, a lot of humor and a penchant for outrageous disguises, Gleason and Carney bust speakeasies in their own madcap manner. When their wily ways pit them against machine-gun-toting gangsters, the laughs fly as fast as the bullets. Guns, Feds and gangsters provide fast-paced excitement in "Izzy & Moe" as Gleason and Carney display the magic that has made them legendary laughmakers.