The Holy Girl poignantly captures the lives of two teenage girls, Amalia, daughter to the owner of the hotel, and the girl's best friend Josefina, as they adjust to their growing sexuality and religious passion. After an encounter with the respected Dr. Jano, a physician attending the convention, Amalia confides in Josefina that she is going to deliver him from sin. After submitting to her wishes, Dr. Jano realizes that no matter how good the temptation, nothing is worth the evil it causes.