After self-help book author and guru Abby McCarthy (Lisa Edelstein) publicly admits that she has separated from her husband Jake (Paul Adelstein), America's once-favorite girlfriend finds her career and marriage in a free fall. Turning away from her married clique and toward her new set of divorced friends, Abby sets out on a journey of self-discovery as she attempts to salvage her career, get back in the dating game and figure out her new identity as a single woman.